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Cardinals vs Jaguars Forecast : November 23, 2025

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The Jacksonville Jaguars travel to Glendale to face the Arizona Cardinals, who are going through one of the toughest moments of their season. With both teams showing very different trends, this Week 12 matchup promises contrast, urgency and a perfect scenario to evaluate contenders and teams looking for air.

Jaguars: Renewed Momentum And A Clear Goal

Jacksonville comes in with a 6-4 record and, above all, with a strong response after a hard blow suffered weeks ago. Their 35-6 win over the Chargers marked a point of stability after the collapse against Houston, a game in which they conceded 26 points in the last quarter alone. That jolt seems to have awakened the team.

The performance against Los Angeles was an example of complete execution: points in all periods, a balanced offense and a defense that never lost control. Trevor Lawrence was not explosive, but he was efficient in key moments: 14 of 22 passes, 153 yards, one touchdown pass and another on the ground. The ground offense combined power and rhythm with Bhayshul Tuten and Travis Etienne, who totaled more than 140 yards and three touchdowns.

Despite this, the coaching staff knows that not everything is working perfectly. Travon Walker left the game with a knee injury, a sensitive blow for a defense that relies heavily on him in the ground game. Other key players such as Anton Harrison, Brian Thomas and Jourdan Lewis are also still under observation.

The point in Jacksonville's favor is clear: when they manage the rhythm, their structure works. They need to repeat that formula, especially against an opponent that is hurting a lot and that defensively suffers in the air containment and in the secondary.

Keys to the Jaguars

  • Controlled pace with Etienne and Tuten.
  • Lawrence avoiding simple mistakes that created problems in previous weeks.
  • Strong defense against the run, second best in the league in yards allowed.

Cardinals: Injuries, Doubts And A Defense That Can't Hold Up

Arizona comes in at 3-7, with seven losses in its last eight games, and with a roster that is adding new players every week. The list of injured players is not only long, but also crucial: Kelvin Beachum, Baron Browning, Will Hernandez, Dadrion Taylor-Demerson, Marvin Harrison Jr., Emari Demercado... all out of practice. Coach Jonathan Gannon has already ruled out Harrison and Demercado, two key pieces of the attack.

Despite the situation, the team had some positive individual moments. In the 41-22 loss to the 49ers, Jacoby Brissett put on a statistical show: 452 yards and 47 pass completions, tying an all-time record. Michael Wilson was dominant with 185 yards on 15 receptions, while Trey McBride topped 100 yards and a touchdown.

But those numbers didn't change the main problem: Arizona's defense isn't responding. They allowed points in every quarter, including double-digit scoring streaks in the first three quarters. That creates a difficult scenario against a team that, like Jacksonville, scores in every quarter when the game opens up.

The only thing that could play in their favor is the reactivation of Trey Benson, who opened his return window from IR and could see action. However, this offense without Harrison and Demercado loses balance and explosiveness.

Keys to the Cardinals

  • Brissett needs to repeat his accuracy to compensate for the lack of offensive pieces.
  • Wilson and McBride consolidate their position as main weapons.
  • The defense must try to keep the game from opening up early.

Cardinals vs Jaguars Forecast

Arizona has the ability to move the ball if Brissett keeps up his level, especially taking advantage of McBride against a defense that suffers against tight ends. That sector can generate yards, but is unlikely to sustain a pace that offsets their defensive woes.

Jacksonville, meanwhile, has been finding balance. Their defense against the run is forcing Brissett to throw even more, which can lead to mistakes. Doug Pederson's game plan seems more stable, while Gannon is trying to patch holes week in and week out.

Coupled with Arizona's long injury list and the recent form of both teams, there is a clear favorite.

Prediction: Jacksonville Jaguars win

Estimated score: Jaguars 27 - Cardinals 17

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